Continuous manufacturing has been applied in many different industries but has been
pursued reluctantly in biotechnology where the batchwise process is still the standard. A …

Over the last years, aqueous two-phase systems (ATPS) regained an increasing interest due
to their potential in the downstream processing of biomolecules. After many years with only a …

Aqueous two phase system (ATPS) is a liquid–liquid extraction method which employs two
aqueous phases having applications in the field of biotechnology for the separation and …

Four kinds of green deep eutectic solvent (DES) were synthesized, including choline
chloride (ChCl)–urea, tetramethylammonium chloride (TMACl)–urea, tetrapropylammonium …

This article reviews technology trends in antibody purification. Section 1 discusses non-
chromatography methods, including precipitation, liquid–liquid extraction, and high …

The number of biotechnology-based pharmaceuticals in the late-stage pipeline has been
increasing more than ever. As a result, there is an enhanced demand for more efficient and …

Aqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for
the separation and purification of high-value biomolecules. However, after more than seven …

The therapeutic use of proteins has created an increasing demand for feasible and
economical methods for both up-and downstream processes. However, whereas upstream …

For half a century aqueous two‐phase systems (ATPSs) have been applied for the extraction
and purification of biomolecules. In spite of their simplicity, selectivity, and relatively low cost …

Process development in the biotech industry leads to investments around hundred of
millions of dollars. It is important to mitigate costs without neglecting the quality of process …