Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate
decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …

The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that
significantly influences cellular metabolism. ESRRA is predominantly expressed in …

Estrogen-related receptor (ERR) γ is an orphan nuclear hormone receptor that belongs to
the ERR subfamily of transcription factors. No endogenous ligand has been identified to …

Objective—Vascular calcification (VC) is an important predictor of cardiovascular morbidity
and mortality. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is a key …

Extracellular vesicles (EVs) possess great potential in the modulation of cardiovascular
diseases. Our current work intended to assay the clinical significance of endothelial cell (EC) …

Objective—Vascular calcification is associated with increased risk of myocardial infarction
and stroke. The objective of this work was to examine the ability of 17β-estradiol (E2) to …

Systemic inflammation is involved in vascular calcification and cardiovascular disease which
is the leading cause of mortality in rheumatoid arthritis (RA). A high level of serum interleukin …

Vascular calcification, the ectopic deposition of calcium in blood vessels, develops in
association with various metabolic diseases and atherosclerosis and is an independent …

Estrogen-related receptors (ERRα, β and γ in mammals) are orphan members of the nuclear
receptor superfamily acting as transcription factors. ERRs are expressed in several cell …

Endocrine disruptors have become a global social and public health problem since the late
1980s. Bisphenol A (BPA) has a steroid-like skeleton similar to estrogen and progesterone …