Telomerase is an attractive cancer target as it appears to be required in essentially all
tumours for immortalization of a subset of cells, including cancer stem cells. Moreover …

Telomere length and cell function can be preserved by the human reverse transcriptase
telomerase (hTERT), which synthesizes the new telomeric DNA from a RNA template, but is …

One of the hallmarks of advanced malignancies is continuous cell growth and this almost
universally correlates with the reactivation of telomerase. Although there is still much we do …

Telomerase activity is dependent on the expression of 2 main core component genes,
hTERT, which encodes the catalytic component and hTR (also called TERC), which …

The telomerase reverse transcriptase (TERT) promoter mutations are associated with
increased TERT mRNA and TERT protein levels, telomerase activity, and shorter but stable …

Telomere length is associated with mutation status of the immunoglobulin heavy chain
variable (IGHV) gene and clinical course in B-cell chronic lymphocytic leukemia (B-CLL). In …

One of the hallmarks of malignant cell populations is the ability to undergo continuous
proliferation. This property allows clonal lineages to acquire sequential aberrations that can …

Telomerase reactivation is a hallmark of human carcinogenesis. Increased telomerase
activity may result from gene amplification and/or overexpression. This study evaluates the …

Eleven years after the start of a new millennium characterized by amazing scientific
development, the cure for cancer remains a major challenge for humanity. In this regard …

Telomeres are located at the ends of eukaryotic chromosomes. Human telomerase, a
cellular reverse transcriptase, is a ribonucleoprotein enzyme that catalyzes the synthesis …