Interleukin (IL)-6 has been studied since its discovery for its role in health and diseases. It is
one of the most important pro-inflammatory cytokines. IL-6 was reported as an exacerbating …

Meteorin-like, also known as Metrnl, Meteorin-β, Subfatin, and Cometin, is a novel secreted
protein exerting pleiotropic effects on inflammation, immunology, and metabolism. Earlier …

The production of metrnl, a novel adipomyokine, is induced upon exercise in adipose tissue
and skeletal muscle. In this study, we investigated the anti-inflammatory and antipyroptotic …

The inflammatory disorders collectively termed the seronegative spondyloarthropathies
(SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the …

Osteoarthritis (OA) is a prevalent progressive disease that frequently coexists with obesity.
For several decades, OA was thought to be the result of ageing and mechanical stress on …

Disclosures: A. Bayes-Genis reported personal fees from Abbott, personal fees from Astra
Zeneca, personal fees from Novartis, personal fees from Vifor, personal fees from …

Background The human enthesis conventional T cells are poorly characterised. Objectives
To study the biology of the conventional T cells in human enthesis. Methods CD4+ and …

Metrnl, a secreted protein expressed in white adipose tissue, has been identified as a novel
adipokine. It is also highly expressed in barrier tissues, including the skin, intestinal and …

Objective The importance of interleukin‐17A (IL‐17A) in the pathogenesis of axial
spondyloarthritis (SpA) has been demonstrated by the success of IL‐17A blockade …

Background Neutrophils are present in the early phases of spondyloarthritis-related uveitis,
skin and intestinal disease, but their role in enthesitis, a cardinal musculoskeletal lesion in …