This paper reviews chemical models of epilepsy and their relevance in the identification and
characterization of anticonvulsants. For each convulsant we discuss possible modes of …

The anticonvulsant activity of uch L059 ((S)-α-cthyl-2-oxo-pyrrolidinc acetamide) was
evaluated in a range of animal models, uch L059 was active after oral and intraperitoneal …

Epilepsy surgery has been successfully performed in patients with tuberous sclerosis
complex (TSC) and seizures arising from a restricted epileptogenic area. The outcome of …

The conantokins are a family of peptides isolated from the venom of predatory marine snails
of the genus Conus. Here we demonstrate that one of these peptides, conantokin-G …

The alcohol withdrawal syndrome has received increased attention over the past 40 years
and it is now well established that the abrupt reduction, or total cessation, of chronic alcohol …

Epileptogenesis is the genesis or creation of a chronic hyperexcitable epileptic state.
Epileptogenesis is one of the most dramatic examples of neuronal plasticity, as can be seen …

The NMDA receptor, a ligand-gated ion channel complex, has been reported to be involved
in memory processes. Learning is impaired following administration of dizocilpine, a non …

A low molecular weight fraction (AG2) containing arylamine compounds has been isolated
from venom of the spiderAgelenopsis aperta. When administered intravenously or …

Recent studies have demonstrated that ethanol is a potent blocker of N-methyl-d-aspartate
(NMDA) receptor mediated responses. It is well known that neuroplasticity processes …

Intracerebroventricular (ICV) administration of κ-agonists (PD 117302, U-50488H and U-
69593) induced convulsions in a dose-related manner in mice. The dose at which 50% of …