Marine organisms are an important source of natural products with unique and diverse
chemical structures that may hold the key for the development of novel drugs …

Atherosclerosis is one of the most important problems of modern medicine as it is the
leading cause of hospitalizations, disability, and mortality. The key role in the development …

Cancer is a process involving cell mutation, increased proliferation, invasion, and
metastasis. Over the years, this condition has represented one of the most concerning health …

Sepsis, a complex clinical syndrome characterized by an exaggerated host response to
infection, often necessitates hospitalization and intensive care unit admission. Delayed or …

Pro-regenerative lipid mediator 1 (PreM1) is a specialized pro-resolving lipid mediator that
promotes wound healing and regenerative functions of mesenchymal stem cells (MSCs) …

Biofilm-associated bacterial infections are the major reason for treatment failure in many
diseases including burn trauma infections. Uncontrolled inflammation induced by bacteria …

The C16–C22 fragment with the acetylene terminus was constructed through the asymmetric
dihydroxylation of the corresponding olefin, while the 15-iodo-olefin corresponding to the …

A convergent strategy was developed for the synthesis of the C12–C40 segment of (–)-
pulvomycin. Key step was a diastereoselective aldol reaction between a chiral ethyl ketone …