Macrophages, which are key cellular components of the liver, have emerged as essential
players in the maintenance of hepatic homeostasis and in injury and repair processes in …

Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …

Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …

Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …

Despite the diverse etiologies of drug-induced liver injury (DILI), innate immunity activation
is a common feature involved in DILI progression. However, the involvement of innate …

Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury
after an overdose. The intracellular signaling mechanisms of APAP-induced cell death such …

Acetaminophen (APAP) overdose is the leading cause of acute liver failure in western
countries. APAP can cause extensive hepatocellular necrosis, which triggers an …

Acetaminophen (APAP) overdose causes acute liver injury and leads to fatal liver damage.
However, the therapies are quite limited. Shikonin is a natural product with antioxidant and …

Background & Aims Beyond the classical description of eosinophil functions in parasite
infections and allergic diseases, emerging evidence supports a critical role of eosinophils in …