The Role of Copper Overload in Modulating Neuropsychiatric Symptoms

M Manchia, P Paribello, M Pinna, G Faa - International Journal of …, 2024 - mdpi.com
Copper is a transition metal essential for growth and development and indispensable for
eukaryotic life. This metal is essential to neuronal function: its deficiency, as well as its …

[HTML][HTML] Atox1 protects hippocampal neurons after traumatic brain injury via DJ-1 mediated anti-oxidative stress and mitophagy

P Zhao, W Shi, Y Ye, K Xu, J Hu, H Chao, ZQ Tao, L Xu… - Redox Biology, 2024 - Elsevier
Regulation of the oxidative stress response is crucial for the management and prognosis of
traumatic brain injury (TBI). The copper chaperone Antioxidant 1 (Atox1) plays a crucial role …

[HTML][HTML] Mechanism of Cu entry into the brain: many unanswered questions

S Roy, S Lutsenko - Neural Regeneration Research, 2024 - journals.lww.com
Brain tissue requires high amounts of copper (Cu) for its key physiological processes, such
as energy production, neurotransmitter synthesis, maturation of neuropeptides, myelination …

[HTML][HTML] SOX4 Mediates ATRA-Induced Differentiation in Neuroblastoma Cells

D Zhang, B Gong, Q Zhao, Z Li, X Tan, Z Hua - Cancers, 2022 - mdpi.com
Simple Summary Neuroblastoma (NB) is considered to be caused by the differentiation
failure of neural crest cells. Researchers are working on exploring the mechanisms of NB …

Wilson disease–causing mutations in the carboxyl terminus of ATP7B regulates its localization and Golgi exit selectively in the unpolarized cells

K Chakraborty, S Das, A Pal, S Maji, B Rai… - Metallomics, 2023 - academic.oup.com
Mutational inactivation of the P-type Cu-ATPase ATP7B interferes with its cellular functions
to varying extent leading to varied cellular phenotypes. Wilson's disease (WD) primarily …

铜进入大脑的机制: 许多悬而未决的问题

S Roy, S Lutsenko - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
Brain tissue requires high amounts of copper (Cu) for its key physiological processes, such
as energy production, neurotransmitter synthesis, maturation of neuropeptides, myelination …