Nedd8 on cullin: building an expressway to protein destruction
This review summarizes recent advances concerning the Nedd8 regulatory pathway in four
areas. One, substantial progress has been made in delineating the role of cullin family …
areas. One, substantial progress has been made in delineating the role of cullin family …
The COP9 signalosome: more than a protease
N Wei, G Serino, XW Deng - Trends in biochemical sciences, 2008 - cell.com
The COP9 signalosome (CSN) is a conserved protein complex that functions in the ubiquitin–
proteasome pathway. After two decades of research, we now know that the CSN is a multi …
proteasome pathway. After two decades of research, we now know that the CSN is a multi …
[HTML][HTML] Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
DP Xirodimas, MK Saville, JC Bourdon, RT Hay… - Cell, 2004 - cell.com
The only reported role for the conjugation of the NEDD8 ubiquitin-like molecule is control of
the activity of SCF ubiquitin ligase complexes. Here, we show that the Mdm2 RING finger E3 …
the activity of SCF ubiquitin ligase complexes. Here, we show that the Mdm2 RING finger E3 …
Protein neddylation and its role in health and diseases
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …
Roles of COP9 signalosome in cancer
The constitutive photomorphogenesis 9 signalosome (COP9 or CSN) is an evolutionarily
conserved multiprotein complex found in plants and animals. Because of the homology …
conserved multiprotein complex found in plants and animals. Because of the homology …
Mammalian COP9 signalosome
J Kato, N Yoneda‐Kato - Genes to Cells, 2009 - Wiley Online Library
The COP9 signalosome (CSN) complex is highly conserved from yeast to human. Although
the plant CSN was first identified as a negative regulator of photomorphogenesis, the …
the plant CSN was first identified as a negative regulator of photomorphogenesis, the …
Multiple functions of Jab1 are required for early embryonic development and growth potential in mice
K Tomoda, N Yoneda-Kato, A Fukumoto… - Journal of Biological …, 2004 - ASBMB
Jab1 interacts with a variety of signaling molecules and regulates their stability in
mammalian cells. As the fifth component of the COP9 signalosome (CSN) complex, Jab1 …
mammalian cells. As the fifth component of the COP9 signalosome (CSN) complex, Jab1 …
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers
The mammalian constitutive photomorphogenesis 9 (COP9) signalosome (CSN), a protein
complex involved in embryonic development, is implicated in cell cycle regulation and the …
complex involved in embryonic development, is implicated in cell cycle regulation and the …
Role of the MPN Subunits in COP9 Signalosome Assembly and Activity, and Their Regulatory Interaction with Arabidopsis Cullin3-Based E3 Ligases
G Gusmaroli, P Figueroa, G Serino, XW Deng - The Plant Cell, 2007 - academic.oup.com
The COP9 signalosome (CSN) is an evolutionarily conserved multisubunit protein complex
that regulates a variety of biological processes. Among its eight subunits, CSN5 and CSN6 …
that regulates a variety of biological processes. Among its eight subunits, CSN5 and CSN6 …
Endometrial small extracellular vesicles regulate human trophectodermal cell invasion by reprogramming the phosphoproteome landscape
A series of cyclical events within the uterus are crucial for pregnancy establishment. These
include endometrial regeneration following menses, under the influence of estrogen …
include endometrial regeneration following menses, under the influence of estrogen …