Polyglutamine aggregation in Huntington disease: does structure determine toxicity?
G Hoffner, P Djian - Molecular neurobiology, 2015 - Springer
Huntington disease is a dominantly inherited disease of the central nervous system. The
mutational expansion of polyglutamine beyond a critical length produces a toxic gain of …
mutational expansion of polyglutamine beyond a critical length produces a toxic gain of …
γ-Glutamylamines and neurodegenerative diseases
TM Jeitner, K Battaile, AJL Cooper - Amino acids, 2013 - Springer
Transglutaminases catalyze the formation of γ-glutamylamines utilizing glutamyl residues
and amine-bearing compounds such as lysyl residues and polyamines. These γ …
and amine-bearing compounds such as lysyl residues and polyamines. These γ …
Neuronal and endothelial transglutaminase-2 expression during experimental autoimmune encephalomyelitis and multiple sclerosis
Abstract Transglutiminase-2 (TG2) is a multifunctional enzyme that has been implicated in
the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and multiple …
the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and multiple …
Pharmacokinetics of cysteamine bitartrate following intraduodenal delivery
R Dohil, BL Cabrera, JA Gangoiti… - Fundamental & …, 2014 - Wiley Online Library
Cysteamine is approved for the treatment of cystinosis and is being evaluated for
Huntington's disease and non‐alcoholic fatty liver disease. Little is known about the …
Huntington's disease and non‐alcoholic fatty liver disease. Little is known about the …
Transglutaminase 2 is involved in homocysteine-induced activation of human THP-1 monocytes
M Curro, C Gangemi, A Gugliandolo… - Free radical …, 2015 - Taylor & Francis
Abstract Aberrant transglutaminase 2 (TG2) expression and protein cross-linking activity
have been associated with several chronic neurodegenerative disorders in which …
have been associated with several chronic neurodegenerative disorders in which …
Transglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross‐Linking Substrate
G Hoffner, A Van Houtteghem… - … in Enzymology: And …, 2011 - Wiley Online Library
Transglutaminase catalyzes the formation of intermolecular isopeptide cross-links between
glutamine and lysine residues of polypeptides [1, 2]. Because the cross-link is covalent and …
glutamine and lysine residues of polypeptides [1, 2]. Because the cross-link is covalent and …
[HTML][HTML] Transglutaminase in neurological disease
G Hoffner, P Djian - Oncotarget, 2017 - ncbi.nlm.nih.gov
Transglutaminase catalyzes the formation of intermolecular isopeptide crosslinks in
polypeptides [7]. Because the crosslink is insensitive to proteolysis, polymers extensively …
polypeptides [7]. Because the crosslink is insensitive to proteolysis, polymers extensively …
Design, synthesis and evaluation of covalent inhibitors for tissue transglutaminase and factor XIIIa
A Akbar - 2019 - ruor.uottawa.ca
Transglutaminases are a family of enzymes expressed in various tissues of our body. Some
are expressed ubiquitously while others are specific to a tissue. Their primary catalytic …
are expressed ubiquitously while others are specific to a tissue. Their primary catalytic …