Biotics (Pre-, pro-, post-) and uremic toxicity: implications, mechanisms, and possible therapies

L Mitrea, M Medeleanu, CR Pop, AM Rotar, DC Vodnar - Toxins, 2023 - mdpi.com
In recent years, more scientific data have pointed out the close connection between
intestinal microbial community, nutritional habits, lifestyle, and the appearance of various …

The AKI-to-CKD Transition: The Role of Uremic Toxins

C André, S Bodeau, S Kamel, Y Bennis… - International Journal of …, 2023 - mdpi.com
After acute kidney injury (AKI), renal function continues to deteriorate in some patients. In a
pro-inflammatory and profibrotic environment, the proximal tubules are subject to …

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) induces cell death through ferroptosis and acts as a trigger of apoptosis in kidney cells

JS Park, DH Kim, HI Choi, CS Kim, EH Bae… - Cell Death & …, 2023 - nature.com
Ferroptosis is a cell death mechanism characterized by intracellular iron accumulation and
lipid peroxidation. Effects of uremic toxins on ferroptosis in the kidney are not well …

Kidney disease and stroke: epidemiology and potential mechanisms of susceptibility

M Bobot, L Suissa, JF Hak, S Burtey… - Nephrology Dialysis …, 2023 - academic.oup.com
Patients with chronic kidney disease (CKD) have an increased risk of both ischaemic and
haemorrhagic stroke compared with the general population. Both acute and chronic kidney …

Ameliorating effect of probiotics in a rat model of chronic kidney disease

T Inatomi, M Honma - PloS one, 2023 - journals.plos.org
Chronic kidney disease is a prevalent and significant disease worldwide. This study
investigated the effects of a medicinal probiotic (BIO-THREE, TOA Biopharma Co., Ltd …

Geriatric nutritional risk index and risk of mortality in critically ill patients with acute kidney injury: a multicenter cohort study

J Xiong, Z Yu, Y Huang, T He, K Yang, J Zhao - Journal of Renal Nutrition, 2023 - Elsevier
Objectives Malnutrition is associated with adverse outcomes in acute or chronic diseases.
However, the prediction value of the Geriatric Nutritional Risk Index (GNRI) in critically ill …

Gut-derived uremic toxins in CKD: an Improved Approach for the evaluation of serum indoxyl sulfate in clinical practice

G Caggiano, L Amodio, A Stasi, NA Colabufo… - International Journal of …, 2023 - mdpi.com
In the past years, indoxyl sulfate has been strongly implicated in kidney disease progression
and contributed to cardiovascular morbidity. Moreover, as a result of its elevated albumin …

Potential interactions between uraemic toxins and drugs: an application in kidney transplant recipients treated with calcineurin inhibitors

C André, G Choukroun, Y Bennis… - Nephrology Dialysis …, 2022 - academic.oup.com
Background The uraemic toxins that accumulate as renal function deteriorates can
potentially affect drug pharmacokinetics. This study's objective was to determine whether …

The role of gut-derived, protein-bound uremic toxins in the cardiovascular complications of acute kidney injury

P Caillard, Y Bennis, I Six, S Bodeau, S Kamel… - Toxins, 2022 - mdpi.com
Acute kidney injury (AKI) is a frequent disease encountered in the hospital, with a higher
incidence in intensive care units. Despite progress in renal replacement therapy, AKI is still …

Acute kidney injury and organ dysfunction: what is the role of uremic toxins?

JI Lara-Prado, F Pazos-Pérez, CE Méndez-Landa… - Toxins, 2021 - mdpi.com
Acute kidney injury (AKI), defined as an abrupt increase in serum creatinine, a reduced
urinary output, or both, is experiencing considerable evolution in terms of our understanding …