Traumatic, tumoral, and infectious bone defects are common in clinics, and create a big
burden on patient's families and society. Calcium phosphate (CaP)-based biomaterials have …

Bone regeneration has gained attention in the biomedical field, which has led to the
development of materials and synthesis methods meant to improve osseointegration and …

Carvacrol is a natural low-cost compound derived from oregano which presents anti-
bacterial properties against both Gram-positive and Gram-negative bacteria. In this work …

Repairing infected bone defects remains a challenge in clinical work. Intractable bacterial
infections and insufficient osseointegration are major concerns for infected bone defects. To …

Fracture-related infection (FRI) is a devastating event, directly affecting fracture healing,
impairing patient function, prolonging treatment, and increasing healthcare costs. Time plays …

Synergistically improving the mechanical and degradable properties of polylactic acid (PLA)
scaffolds and endowing them with bioactivity are urgent problems to be solved in deepening …

Closed femoral shaft fracture is caused by high-energy injuries, and non-union exists after
operation, which can significantly damage patients' body and mind. This study aimed to …

Introduction Managing distal femur fracture nonunion is complex, with unpredictable results.
The present investigation systematically updates current evidence, reviews existing …

There is an increasing demand for innovative strategies that effectively promote
osteogenesis and enhance bone regeneration. The critical process of bone regeneration …

Background Osteoporosis, a prevalent bone disorder, results in reduced bone mineral
density and mass. With minimal side effects, medicinal plant-based natural remedies are …