In striated muscle, the protein troponin complex turns contraction on and off in a calcium-
dependent manner. The calcium-sensing component of the complex is troponin C, which is …

More than a century of research on the Frank–Starling Law has significantly advanced our
knowledge about the working heart. The Frank–Starling Law mandates that the heart is able …

Myofilament calcium sensitivity is an often-used indicator of cardiac muscle function, often
assessed in disease states such as hypertrophic cardiomyopathy (HCM) and dilated …

Aim Mutations in the RS-domain of RNA-binding motif protein 20 (RBM20) have recently
been identified to segregate with aggressive forms of familial dilated cardiomyopathy (DCM) …

Cardiac muscle relaxation is an essential step in the cardiac cycle. Even when the
contraction of the heart is normal and forceful, a relaxation phase that is too slow will limit …

COVID-19, a pandemic disease caused by a viral infection, is associated with a high
mortality rate. Most of the signs and symptoms, eg cytokine storm, electrolytes imbalances …

Significance: Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease
characterized by left ventricular hypertrophy, diastolic dysfunction, and myocardial disarray …

The formulation by Starling of The Law of the Heart states that 'the [mechanical] energy of
contraction, however measured, is a function of the length of the muscle fibre'. Starling later …

Abstract The Frank–Starling Law dictates that the heart is able to match ejection to the
dynamic changes occurring during cardiac filling, hence efficiently regulating isovolumetric …

The Frank-Starling relation is a fundamental auto-regulatory property of the heart that
ensures the volume of blood ejected in each heartbeat is matched to the extent of venous …