The heart is lined by a single layer of mesothelial cells called the epicardium that provides
important cellular contributions for embryonic heart formation. The epicardium harbors a …

After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …

Human diseases are often caused by loss of somatic cells that are incapable of re-entering
the cell cycle for regenerative repair. Here, we report a combination of cell-cycle regulators …

Adult mammalian cardiomyocyte regeneration after injury is thought to be minimal.
Mononuclear diploid cardiomyocytes (MNDCMs), a relatively small subpopulation in the …

Zebrafish display a distinct ability to regenerate their heart following injury. However, this
ability is not shared by another teleost, the medaka. In order to identify cellular and …

Adult humans fail to regenerate their hearts following injury, and this failure to regenerate
myocardium is a leading cause of heart failure and death worldwide. Although all adult …

The adult human heart does not regenerate significant amounts of lost tissue after injury.
Rather than making new, functional muscle, human hearts are prone to scarring and …

Cardiovascular disease is the leading cause of death worldwide. Compared to other organs
such as the liver, the adult human heart lacks the capacity to regenerate on a macroscopic …

In the zebrafish (Danio rerio), regeneration and fibrosis after cardiac injury are not mutually
exclusive responses. Upon cardiac cryoinjury, collagen and other extracellular matrix (ECM) …

Evolutionary developmental biology, or Evo-Devo for short, has become an established field
that, broadly speaking, seeks to understand how changes in development drive major …