Key Clinical Points Primary Ovarian Insufficiency Primary ovarian insufficiency should be
considered in women younger than 40 years of age who present with new-onset irregular …

Profound environmental, hormonal, and neurobiological changes mark the transition to
motherhood as a major biosocial life event. Despite the ubiquity of motherhood, the …

Despite widespread sex differences in prevalence and presentation of numerous illnesses
affecting the human brain, there has been little focus on the effect of endocrine ageing. Most …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for
more than half of all dementia cases in the elderly. Interestingly, the clinical manifestations of …

Introduction Sex differences in dementia risk, and risk factor (RF) associations with
dementia, remain uncertain across diverse ethno‐regional groups. Methods A total of …

Although there are several genome-wide association studies available which highlight
genetic variants associated with Alzheimer's disease (AD), often the X chromosome is …

An “old wives' tale” is a traditional truth not based on fact (1). The term is now an outmoded
and disrespectful vernacular about women (2). Many spurious truths about menopause have …

Background To date, there is no homogeneous evidence of whether earlier age at
menopause is associated with incident dementia. In addition, the underlying mechanism …

STUDY QUESTION Are there associations between natural or surgical menopause and
incident dementia by age at menopause? SUMMARY ANSWER Compared to age at …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder responsible for over
half of dementia cases, with two-thirds being women. Growing evidence from preclinical and …