Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

Among the various types of cell-to-cell signaling, paracrine signaling comprises those
signals that are transmitted over short distances between different cell types. In the human …

Although fibroblast growth factors are potent angiogenic factors, they may indirectly control
neovascularization in concert with other growth factors. Thus, the unique role played by …

The age-adjusted prevalence of peripheral arterial disease in the US population was
estimated to approach 12% in 1985, and as the population ages, the overall population …

BACKGROUND: Angiogenic cell therapy by intramuscular injection of autologous bone
marrow mononuclear cells was first attempted in patients with peripheral artery disease …

Bone-marrow-derived EPCs (endothelial progenitor cells) play an integral role in the
regulation and protection of the endothelium, as well as new vessel formation. Peripheral …

A number of preclinical studies have indicated the therapeutic potential of endothelial
progenitor cells for vascular regeneration in ischemic diseases. A phase I/IIa clinical trial of …

Heart failure carries a poor prognosis with few treatment options. While myocardial stem cell
therapeutic trials have traditionally relied on intracoronary infusion or intramyocardial …

Peripheral artery disease (PAD) poses a great challenge to society, with a growing
prevalence in the upcoming years. Patients in the severe stages of PAD are prone to …

Noncellular differentiation effects have emerged as important mechanisms mediating
therapeutic effects of stem or progenitor cell transplantation. Here, we investigated the …