Heterotrimeric guanine-nucleotide-binding regulatory proteins (G-proteins) mainly relay the
information from G-protein-coupled receptors (GPCRs) on the plasma membrane to the …

The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …

During the past few years, crystallography of G protein–coupled receptors (GPCRs) has
experienced exponential growth, resulting in the determination of the structures of 16 distinct …

Dopamine modulates movement, cognition, and emotion through activation of dopamine G
protein–coupled receptors in the brain. The crystal structure of the human dopamine D3 …

Abstract HTRF (H omogeneous T ime R esolved F luorescence) is the most frequently used
generic assay technology to measure analytes in a homogenous format, which is the ideal …

G protein–coupled receptors (GPCRs) mediate transmembrane signaling. Before ligand
binding, GPCRs exist in a basal state. Crystal structures of several GPCRs bound with …

G protein-coupled receptors (GPCRs) are important drug targets that mediate various
signaling pathways by activating G proteins and engaging β-arrestin proteins. Despite its …

Receptor heteromers constitute a new area of research that is reshaping our thinking about
biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we …

G‐protein‐coupled receptors (GPCRs) can form heteromeric complexes. Herein'we describe
a new approach to test the heteromerization of 2 receptors' or 2 receptor subunits' and to …

G protein–coupled receptor (GPCR) oligomers have been proposed to play critical roles in
cell signaling, but confirmation of their existence in a native context remains elusive, as no …