Transcriptional regulators encoded by the M yocyte E nhancer F actor 2 (MEF2) gene family
play a fundamental role in cardiac development, homeostasis and pathology. Previous …

The FERM domain is a conserved and widespread protein module that appeared in the
common ancestor of amoebae, fungi, and animals, and is therefore now found in a wide …

The members of the evolutionary conserved actin-binding Ezrin, Radixin and Moesin (ERM)
protein family are involved in numerous key cellular processes in the cytoplasm. In the last …

The ERM protein family, which consists of three closely related proteins in vertebrates, ezrin,
radixin, and moesin (ERM), is an ancient and important group of cytoplasmic actin-binding …

The cytoskeleton of mammal oocytes provides structural support to the plasma membrane
and contributes to critical cellular dynamic processes such as nuclear positioning, germinal …

Background Neuroblastoma is the most common cancer in infants and the most common
extracranial solid tumor in childhood. DRR1 was identified to be downregulated in poorly …

Much evidence supports the presence of cytoskeletal elements in the nucleus; however, the
exact functions of these proteins in the nucleus are still uncertain. Of the cytoskeletal …

Intrinsically disordered proteins (IDPs) are a specific and diverse group of proteins that,
under physiological environmental conditions, do not possess higher levels of structural …

Macromolecules no bigger in size than~ 60 kDa, small molecules and ions are capable of
passive diffusion through the Nuclear Pore Complex (NPC)(Wang and Brattain, 2007) …

The cortical actomyosin cytoskeleton generates the mechanical force driving highly dynamic
processes occurring during epithelial morphogenesis, such as cell shape changes during …