The multifarious roles of the chemokine CXCL14 in cancer progression and immune responses
JA Westrich, DW Vermeer, PL Colbert… - Molecular …, 2020 - Wiley Online Library
The chemokine CXCL14 is a highly conserved, homeostatic chemokine that is constitutively
expressed in skin epithelia. Responsible for immune cell recruitment and maturation, as well …
expressed in skin epithelia. Responsible for immune cell recruitment and maturation, as well …
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Abstract Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and
CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Chromosome 17q21 genes ORMDL3 and GSDMB in asthma and immune diseases
Chromosome 17q21 contains a cluster of genes including ORMDL3 and GSDMB, which
have been highly linked to asthma in genome-wide association studies. ORMDL3 is …
have been highly linked to asthma in genome-wide association studies. ORMDL3 is …
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral …
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …
Proteomic biomarkers of progressive fibrosing interstitial lung disease: a multicentre cohort analysis
WS Bowman, CA Newton, AL Linderholm… - The Lancet …, 2022 - thelancet.com
Background Progressive fibrosing interstitial lung disease (ILD) is characterised by
parenchymal scar formation, leading to high morbidity and mortality. The ability to predict …
parenchymal scar formation, leading to high morbidity and mortality. The ability to predict …
GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation
S Das, M Miller, AK Beppu, J Mueller… - Proceedings of the …, 2016 - National Acad Sciences
Gasdermin B (GSDMB) on chromosome 17q21 demonstrates a strong genetic linkage to
asthma, but its function in asthma is unknown. Here we identified that GSDMB is highly …
asthma, but its function in asthma is unknown. Here we identified that GSDMB is highly …
Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17
JL Maravillas-Montero, AM Burkhardt… - The Journal of …, 2015 - journals.aai.org
Chemokines are chemotactic cytokines that direct the traffic of leukocytes and other cells in
the body. Chemokines bind to G protein–coupled receptors expressed on target cells to …
the body. Chemokines bind to G protein–coupled receptors expressed on target cells to …
CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans
CXCL17 is a chemokine principally expressed by mucosal tissues, where it facilitates
chemotaxis of monocytes, dendritic cells, and macrophages and has antimicrobial …
chemotaxis of monocytes, dendritic cells, and macrophages and has antimicrobial …
GPR35 in intestinal diseases: from risk gene to function
B Kaya, H Melhem, JH Niess - Frontiers in immunology, 2021 - frontiersin.org
Diet and gut microbial metabolites mediate host immune responses and are central to the
maintenance of intestinal health. The metabolite-sensing G-protein coupled receptors …
maintenance of intestinal health. The metabolite-sensing G-protein coupled receptors …
G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease
N Divorty, AE Mackenzie, SA Nicklin… - Frontiers in …, 2015 - frontiersin.org
G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has
garnered interest as a potential therapeutic target through its association with a range of …
garnered interest as a potential therapeutic target through its association with a range of …