Hepatitis C treatment: where are we now?

NJ Burstow, Z Mohamed, AI Gomaa… - … journal of general …, 2017 - Taylor & Francis
Chronic hepatitis C infection affects millions of people worldwide and confers significant
morbidity and mortality. Effective treatment is needed to prevent disease progression and …

[HTML][HTML] Overview of hepatitis C infection, molecular biology, and new treatment

AA Rabaan, SH Al-Ahmed, AM Bazzi… - Journal of infection and …, 2020 - Elsevier
Abstract The World Health Organization estimates that 71 million people worldwide have
chronic hepatitis C viral infection. A major challenge is overall lack of public awareness of …

[HTML][HTML] 2020 Taiwan consensus statement on the management of hepatitis C: part (I) general population

ML Yu, PJ Chen, CY Dai, TH Hu, CF Huang… - Journal of the Formosan …, 2020 - Elsevier
Hepatitis C virus (HCV) infection remains a major public health issue with high prevalence in
Taiwan. Recently, the advent of direct-acting antiviral (DAA) agents, with higher efficacy …

Direct-acting antivirals: the endgame for hepatitis C?

R D'Ambrosio, E Degasperi, M Colombo… - Current opinion in …, 2017 - Elsevier
Highlights•DAAs for HCV treatment include protease (NS3/4A) inhibitors, RNA-dependent
polymerase (NS5B) inhibitors and NS5A inhibitors.•The combination of DAA owning to …

Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE …

I Waked, G Shiha, RB Qaqish, G Esmat… - The Lancet …, 2016 - thelancet.com
Summary Background In Egypt, chronic hepatitis C virus (HCV) infection occurs in around
10% of the population (about 8 million individuals), and is a leading cause of liver cirrhosis …

[HTML][HTML] Decade of optimizing therapy with direct-acting antiviral drugs and the changing profile of patients with chronic hepatitis C

M Brzdęk, D Zarębska-Michaluk… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Chronic infection with the hepatitis C virus (HCV) remains a major health problem affecting
approximately 58 million people worldwide. In the era of interferon (IFN)-based regimens …

Introduction to hepatitis C virus infection: Overview and history of hepatitis C virus therapies

L Puchades Renau, M Berenguer - Hemodialysis International, 2018 - Wiley Online Library
Chronic hepatitis C virus (HCV) infection is an infection that affects over 71 million people
worldwide that primarily leads to significant morbidity and mortality through its predisposition …

Real‐world effectiveness of ombitasvir/paritaprevir/ritonavir±dasabuvir±ribavirin in patients with hepatitis C virus genotype 1 or 4 infection: A meta‐analysis

H Wedemeyer, A Craxí, E Zuckerman… - Journal of viral …, 2017 - Wiley Online Library
The direct‐acting antiviral regimen of ombitasvir (OBV)/paritaprevir (PTV)/ritonavir
(r)±dasabuvir (DSV)±ribavirin (RBV) demonstrated high rates of sustained viral response at …

Ledipasvir/sofosbuvir with or without ribavirin for 8 or 12 weeks for the treatment of HCV genotype 4 infection: results from a randomised phase III study in Egypt

G Shiha, G Esmat, M Hassany, R Soliman, M Elbasiony… - Gut, 2019 - gut.bmj.com
Objective We evaluated the efficacy and safety of ledipasvir/sofosbuvir alone and with
ribavirin for 8 and 12 weeks in Egyptian patients with and without cirrhosis, who were …

[HTML][HTML] Changes in characteristics of patients with hepatitis C virus-related cirrhosis from the beginning of the interferon-free era

M Brzdęk, D Zarębska-Michaluk… - World Journal of …, 2023 - ncbi.nlm.nih.gov
BACKGROUND Nearly 290000 patients with chronic hepatitis C die annually from the most
severe complications of the disease. One of them is liver cirrhosis, which occurs in about …