The identification of individual protein-protein interactions (PPIs) began more than 40 years
ago, using protein affinity chromatography and antibody co-immunoprecipitation. As new …

While the primary sequences of human proteins have been cataloged for over a decade,
determining how these are organized into a dynamic collection of multiprotein assemblies …

Upon DNA damage, numerous proteins are targeted for ubiquitin-dependent proteasomal
degradation, which is an integral part of the DNA repair program. Although details of the …

Translating high-confidence (hc) autism spectrum disorder (ASD) genes into viable
treatment targets remains elusive. We constructed a foundational protein-protein interaction …

Gene knock‐out (KO) mouse models for DNA polymerase beta (Polβ) revealed that loss of
Polβ leads to neonatal lethality, highlighting the critical organismic role for this DNA …

Endometrial cancer has been associated with pathogenic variants in mismatch repair (MMR)
genes, especially in the context of the hereditary Lynch Syndrome. More recently …

Background Bivalent regions of chromatin (BvCR) are characterized by trimethylated lysine
4 (H3K4me3) and lysine 27 on histone H3 (H3K27me3) deposition which aid gene …

Mutations in isocitrate dehydrogenase isoform 1 (IDH1) are primarily found in secondary
glioblastoma (GBM) and low-grade glioma but are rare in primary GBM. The standard …

ADP‐ribosylation is a reversible post‐translational modification that plays a role as a
signaling mechanism in various cellular processes. This modification is characterized by its …

Understanding the roles of human proteins remains a major challenge, with approximately
20% of human proteins lacking known functions and more than 40% missing context …