Genetic or nutritional deficiencies in homocysteine (Hcy) metabolism lead to
hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of …

Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is the most common
type of spinocerebellar ataxia in China. However, the pathogenesis of SCA3/MJD is still …

The use of untargeted metabolomics for the discovery of markers is a promising and virtually
unexplored tool in the doping control field. Hybrid quadrupole time-of-flight (QTOF) and …

Background High throughput protein expression studies can be performed using bead-
based protein immunoassays, such as the Luminex® xMAP® technology. Technical …

The analysis and the interpretation of the complex and dynamic biological systems has
become a major bottleneck nowadays. The latest high-throughput “omics” approaches, such …

Aim: Subclinical pathological features in renal allograft biopsies predict poor outcomes, and
noninvasive biomarkers are wanted. RNA quantification in urine predicts overt rejection. We …

DNA microarrays, which are among the most popular genomic tools, are widely applied in
biology and medicine. Boutique arrays, which are small, spotted, dedicated microarrays …

Background One of the most important application spectrums of transcriptomic data is
cancer phenotype classification. Many characteristics of transcriptomic data, such as …

In angiosperms, desiccation tolerance, a genetic trait that enables tissues to survive loss of
more than 95% of cellular water is widely observed in the seeds, but is only found in the …

Secondary degeneration following an initial injury to neural tissue results in increased tissue
loss and widespread functional impairments. This thesis characterised the mechanisms of …