Natural Killer (NK) cells are a type of innate lymphoid cells that play a crucial role in
immunity by killing virally infected or tumor cells and secreting cytokines and chemokines …

One of the main challenges in the development of bioprocesses based on cell transient
expression is the commonly reported reduction of cell specific productivity at increasing cell …

Double-strand breaks (DSBs) in DNA are challenging to repair. Cells employ at least three
DSB-repair mechanisms, with a preference for non-homologous end joining (NHEJ) over …

Serum-free cultures are preferred for application in clinical cell therapy and facilitate the
purification processes of bioproducts, such as vaccines and recombinant proteins. It can …

Simple Summary Glioblastoma (GB) is the most common and aggressive type of malignant
brain tumor; however, despite advances in treatment modalities, it remains largely incurable …

Exosome-derived microRNAs (miRNAs) are biomacromolecules and nanoscale
extracellular vesicles originating from intracellular compartments that are secreted by most …

Packaging or producer cell lines for scalable recombinant adeno-associated virus (rAAV)
production have been notoriously difficult to create due in part to the cytostatic nature of the …

Cell counting is a vital practice in the maintenance and manipulation of cell cultures. It is a
crucial aspect of assessing cell viability and determining proliferation rates, which are …

The CRISPR/Cas system has emerged as a powerful tool for genome editing in metabolic
engineering and human gene therapy. However, locating the optimal site on the …

Adeno-associated viruses (AAVs) are non-enveloped ssDNA icosahedral T= 1 viruses used
as vectors for clinical gene delivery. Currently, there are over 200 AAV-related clinical trials …