Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …

Use of telomere length (TL) as a biomarker for various environmental exposures and
diseases has increased in recent years. Various methods have been developed to measure …

Pangenomes provide access to an accurate representation of the genetic diversity of
species, both in terms of sequence polymorphisms and structural variants (SVs). Here we …

Maintenance of a minimal telomere length is essential to prevent cellular senescence. When
critically short telomeres arise in the absence of telomerase, they can be repaired by …

The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …

We developed a method to tag telomeres and measure telomere length by nanopore
sequencing in the yeast S. cerevisiae. Nanopore allows long-read sequencing through the …

The model for telomere shortening at each replication cycle is currently incomplete, and the
exact contribution of the telomeric 3′ overhang to the shortening rate remains unclear …

The paradigm of chemical activation rates in cellular biology has been shifted from the mean
arrival time of a single particle to the mean of the first among many particles to arrive at a …

Oxidative stress (OS)-induced senescence of the amniochorion has been associated with
parturition at term. We investigated whether telomere fragments shed into the amniotic fluid …

The concept of progressive fibrosing interstitial lung disease (PF-ILD) has recently emerged.
However, real-life proportion of PF-ILDs outside IPF is still hard to evaluate. Therefore, we …