Conventional and emerging strategies for the fabrication and functionalization of PDMS-based microfluidic devices

A Shakeri, S Khan, TF Didar - Lab on a Chip, 2021 - pubs.rsc.org
Microfluidics is an emerging and multidisciplinary field that is of great interest to
manufacturers in medicine, biotechnology, and chemistry, as it provides unique tools for the …

Clamping strategies for organ-on-a-chip devices

DJ Teixeira Carvalho, L Moroni… - Nature Reviews Materials, 2023 - nature.com
Organ-on-a-chip devices have enabled major breakthroughs in biomedical research, but
they have yet to be successfully translated to the pharmaceutical industry. Traditional …

Design and fabrication of a liver-on-a-chip platform for convenient, highly efficient, and safe in situ perfusion culture of 3D hepatic spheroids

LD Ma, YT Wang, JR Wang, JL Wu, XS Meng, P Hu… - Lab on a Chip, 2018 - pubs.rsc.org
Spheroid-based three-dimensional (3D) liver culture models, offering a desirable biomimetic
microenvironment, are useful for recapitulating liver functions in vitro. However, a user …

Liver-on-a-chip devices: the pros and cons of complexity

P Dalsbecker, C Beck Adiels… - American Journal of …, 2022 - journals.physiology.org
Physiologically relevant and broadly applicable liver cell culture platforms are of great
importance in both drug development and disease modeling. Organ-on-a-chip systems offer …

Experimental study of PDMS bonding to various substrates for monolithic microfluidic applications

R Gajasinghe, SU Senveli, S Rawal… - Journal of …, 2014 - iopscience.iop.org
This paper presents a comprehensive experimental study and characterization of material
and bonding of PDMS based structures to various substrates. A previously published …

A handy reversible bonding technology and its application on fabrication of an on-chip liquid metal micro-thermocouple

J Hong, J Gong, Q Li, Z Deng, L Gui - Lab on a Chip, 2021 - pubs.rsc.org
We report a novel reversible bonding technique for liquid metal (LM) microelectrode
fabrication in this study. This technique greatly simplifies the process of LM micro-electrode …

Instantaneous room temperature bonding of a wide range of non-silicon substrates with poly (dimethylsiloxane)(PDMS) elastomer mediated by a mercaptosilane

W Wu, J Wu, JH Kim, NY Lee - Lab on a Chip, 2015 - pubs.rsc.org
This paper introduces an instantaneous and robust strategy for bonding a variety of non-
silicon substrates such as thermoplastics, metals, an alloy, and ceramics to poly …

Self-regenerating and hybrid irreversible/reversible PDMS microfluidic devices

LS Shiroma, MHO Piazzetta, GF Duarte-Junior… - Scientific reports, 2016 - nature.com
This paper outlines a straightforward, fast, and low-cost method to fabricate
polydimethylsiloxane (PDMS) chips. Termed sandwich bonding (SWB), this method requires …

Reversible bonding of microfluidics: Review and applications

Y Zhang, K Sun, Y Xie, K Liang, J Zhang… - Review of Scientific …, 2023 - pubs.aip.org
With the development of microfluidic technology, new materials and fabrication methods
have been constantly invented in the field of microfluidics. Bonding is one of the key steps …

From cleanroom to desktop: emerging micro-nanofabrication technology for biomedical applications

T Pan, W Wang - Annals of biomedical engineering, 2011 - Springer
This review is motivated by the growing demand for low-cost, easy-to-use, compact-size yet
powerful micro-nanofabrication technology to address emerging challenges of fundamental …