Cell sheet tissue engineering: cell sheet preparation, harvesting/manipulation, and transplantation

J Kobayashi, A Kikuchi, T Aoyagi… - Journal of biomedical …, 2019 - Wiley Online Library
Cell sheet tissue engineering is a concept for creating transplantable two‐dimensional (2D)
and three‐dimensional (3D) tissues and organs. This review describes three elements of …

Opportunities and challenges in cardiac tissue engineering from an analysis of two decades of advances

RZ Zhuang, R Lock, B Liu… - Nature Biomedical …, 2022 - nature.com
Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …

In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels

H Sekine, T Shimizu, K Sakaguchi, I Dobashi… - Nature …, 2013 - nature.com
In vitro fabrication of functional vascularized three-dimensional tissues has been a long-
standing objective in the field of tissue engineering. Here we report a technique to engineer …

Maturation of human induced pluripotent stem cell-derived cardiomyocytes by soluble factors from human mesenchymal stem cells

S Yoshida, S Miyagawa, S Fukushima, T Kawamura… - Molecular Therapy, 2018 - cell.com
In this study, we proposed that the functionality or phenotype of differentiated
cardiomyocytes derived from human induced pluripotent stem cells (iPSC-CMs) might be …

[HTML][HTML] Progress and challenges in large-scale expansion of human pluripotent stem cells

C Kropp, D Massai, R Zweigerdt - Process Biochemistry, 2017 - Elsevier
The constant supply of high cell numbers generated by defined, robust, and economically
viable culture processes is indispensable for the envisioned application of human …

Cell sheet approach for tissue engineering and regenerative medicine

K Matsuura, R Utoh, K Nagase, T Okano - Journal of Controlled Release, 2014 - Elsevier
After the biotech medicine era, regenerative medicine is expected to be an advanced
medicine that is capable of curing patients with difficult-to-treat diseases and physically …

Enhanced survival of transplanted human induced pluripotent stem cell–derived cardiomyocytes by the combination of cell sheets with the pedicled omental flap …

M Kawamura, S Miyagawa, S Fukushima, A Saito… - Circulation, 2013 - Am Heart Assoc
Background—Transplantation of cardiomyocytes that are derived from human induced
pluripotent stem cell–derived cardiomyocytes (hiPS-CMs) shows promise in generating new …

Assembling living building blocks to engineer complex tissues

L Ouyang, JPK Armstrong… - Advanced Functional …, 2020 - Wiley Online Library
The great demand for tissue and organ grafts, compounded by an aging demographic and a
shortage of available donors, has driven the development of bioengineering approaches …

Thermally-triggered fabrication of cell sheets for tissue engineering and regenerative medicine

H Takahashi, T Okano - Advanced drug delivery reviews, 2019 - Elsevier
Cell transplantation is a promising approach for promoting tissue regeneration in the
treatment of damaged tissues or organs. Although cells have conventionally been delivered …

Transplantation of human-induced pluripotent stem cell-derived cardiomyocytes is superior to somatic stem cell therapy for restoring cardiac function and oxygen …

M Ishida, S Miyagawa, A Saito, S Fukushima… - …, 2019 - journals.lww.com
Background Somatic stem cell (SC) therapy can improve cardiac performance following
ischemic injury. In this study, we investigated whether induced pluripotent SC-derived …