TRIM21/Ro52-roles in innate immunity and autoimmune disease
TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …
Protective mechanisms of nonneutralizing antiviral antibodies
TL Chandler, A Yang, CE Otero, SR Permar… - Plos …, 2023 - journals.plos.org
Antibodies that can bind to viruses but are unable to block infection in cell culture are known
as “nonneutralizing antibodies.” Such antibodies are nearly universally elicited following …
as “nonneutralizing antibodies.” Such antibodies are nearly universally elicited following …
TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models
Although radiotherapy can promote antitumour immunity, the mechanisms underlying this
phenomenon remain unclear. Here, we demonstrate that the expression of the E3 ubiquitin …
phenomenon remain unclear. Here, we demonstrate that the expression of the E3 ubiquitin …
Single-dose mucosal replicon-particle vaccine protects against lethal Nipah virus infection up to 3 days after vaccination
SR Welch, JR Spengler, SC Genzer… - Science …, 2023 - science.org
Nipah virus (NiV) causes a highly lethal disease in humans who present with acute
respiratory or neurological signs. No vaccines against NiV have been approved to date …
respiratory or neurological signs. No vaccines against NiV have been approved to date …
Target-induced clustering activates Trim-Away of pathogens and proteins
J Zeng, AF Santos, AS Mukadam, M Osswald… - Nature structural & …, 2021 - nature.com
Trim-Away is a recently developed technology that exploits off-the-shelf antibodies and the
RING E3 ligase and cytosolic antibody receptor TRIM21 to carry out rapid protein depletion …
RING E3 ligase and cytosolic antibody receptor TRIM21 to carry out rapid protein depletion …
Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge
Humans have four IgG antibody subclasses that selectively or differentially engage immune
effector molecules to protect against infections. Although IgG1 has been studied in detail …
effector molecules to protect against infections. Although IgG1 has been studied in detail …
Development and preclinical evaluation of virus‐like particle vaccine against COVID‐19 infection
Background Vaccines that incorporate multiple SARS‐CoV‐2 antigens can further broaden
the breadth of virus‐specific cellular and humoral immunity. This study describes the …
the breadth of virus‐specific cellular and humoral immunity. This study describes the …
The role of cell-mediated immunity against influenza and its implications for vaccine evaluation
Y Janssens, J Joye, G Waerlop, F Clement… - Frontiers in …, 2022 - frontiersin.org
Influenza vaccines remain the most effective tools to prevent flu and its complications.
Trivalent or quadrivalent inactivated influenza vaccines primarily elicit antibodies towards …
Trivalent or quadrivalent inactivated influenza vaccines primarily elicit antibodies towards …
Analysis of serological biomarkers of SARS-CoV-2 infection in convalescent samples from severe, moderate and mild COVID-19 cases
Precision monitoring of antibody responses during the COVID-19 pandemic is increasingly
important during large scale vaccine rollout and rise in prevalence of Severe Acute …
important during large scale vaccine rollout and rise in prevalence of Severe Acute …
Rotavirus research: 2014–2020
Rotaviruses are major causes of acute gastroenteritis in infants and young children
worldwide and also cause disease in the young of many other mammalian and of avian …
worldwide and also cause disease in the young of many other mammalian and of avian …