Microtubule plus-end tracking proteins (+ TIPs) are a diverse group of evolutionarily
conserved cellular factors that accumulate at the ends of growing microtubules. They form …

First described 15 years ago as a cysteine-rich sequence that was common to a small group
of homeodomain transcription factors, the LIM domain is now recognized as a tandem zinc …

Many lipid-tethered proteins and glycolipids exist as monomers and nanoclusters on the
surface of living cells. The spatial distribution and dynamics of formation and breakup of …

The dynamic remolding of the actin cytoskeleton is a critical part of most cellular activities,
and malfunction of cytoskeletal proteins results in various human diseases. The transition …

Mechanical forces direct a host of cellular and tissue processes. Although much emphasis
has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless …

Kinetochores are proteinaceous assemblies that mediate the interaction of chromosomes
with the mitotic spindle. The 180 kDa Ndc80 complex is a direct point of contact between …

Paxillin is a multi-domain scaffold protein that localizes to the intracellular surface of sites of
cell adhesion to the extracellular matrix. Through the interactions of its multiple protein …

Different types of cell behavior, including growth, motility, and navigation, require actin
proteins to assemble into filaments. Here, we describe a biochemical process that was able …

Microtubules are cytoskeletal filaments that are intrinsically polarized, with two structurally
and functionally distinct ends, the plus end and the minus end. Over the last decade …

The serine/threonine kinase Akt (also called protein kinase B) is well known as an important
regulator of cell survival and growth and has also been shown to be required for cell …