Despite remarkable successes in the clinic, cancer targeted therapy development remains
challenging and the failure rate is disappointingly high. This problem is partly due to the …

Structural variations (SVs) affect more of the cancer genome than any other type of somatic
genetic alteration but difficulties in detecting and interpreting them have limited our …

The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …

Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …

Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Developing therapeutic agents with potent antitumor activity that spare normal tissues
remains a significant challenge. Clonal loss of heterozygosity (LOH) is a widespread and …

Malignant peripheral nerve sheath tumor (MPNST), an aggressive soft-tissue sarcoma,
occurs in people with neurofibromatosis type 1 (NF1) and sporadically. Whole-genome and …

The ability of nanopore sequencing to simultaneously detect modified nucleotides while
producing long reads makes it ideal for detecting and phasing allele-specific methylation …

Large-scale chromosomal aberrations are prevalent in human cancer, but their function
remains poorly understood. We established chromosome-engineered hepatocellular …