Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
Computational modeling of realistic cell membranes
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …
cell, where key processes such as selective transport of material and exchange of …
[HTML][HTML] Interaction mechanism of three egg protein derived ACE inhibitory tri-peptides and DPPC membrane using FS, FTIR, and DSC studies
H Ji, W Zhao, Z Yu - Food Chemistry: X, 2022 - Elsevier
Understanding the interaction of food derived angiotensin converting enzyme (ACE)
inhibitory peptides and intestinal epithelial cell membrane may help to improve their …
inhibitory peptides and intestinal epithelial cell membrane may help to improve their …
Mechanism of interactions between egg protein–derived tri‐peptides and cellular membrane by molecular dynamic simulation and isothermal titration calorimetry
H Ji, W Zhao, Z Yu, S Wu - International Journal of Food …, 2022 - Wiley Online Library
Poor understanding of the absorption of food‐derived angiotensin‐converting enzyme
(ACE) inhibitory peptides across the membrane limits their application in regulating and …
(ACE) inhibitory peptides across the membrane limits their application in regulating and …
Modulatory role of copper on hIAPP aggregation and toxicity in presence of insulin
Aggregation of the human islets amyloid polypeptide, or hIAPP, is linked to β-cell death in
type II diabetes mellitus (T2DM). Different pancreatic β-cell environmental variables such as …
type II diabetes mellitus (T2DM). Different pancreatic β-cell environmental variables such as …
Evidence of the different effect of mercury and cadmium on the hIAPP aggregation process
Abstract hIAPP is a hormone consisting of 37 aminoacids that shows a strong tendency to
self-assemble into β-sheet-rich aggregates, which evolve to form insoluble aggregates that …
self-assemble into β-sheet-rich aggregates, which evolve to form insoluble aggregates that …
Phytoconstituents of Ashwagandha as potential inhibitors of human islet amyloid polypeptide (hIAPP): an in silico investigation
Amylin or human islet amyloid polypeptide (hIAPP) is a small peptide co-secreted with
insulin. Its peripheral aggregation on the lipid bilayer leads to fibril formation. The formation …
insulin. Its peripheral aggregation on the lipid bilayer leads to fibril formation. The formation …
Critical nucleus of Greek-key-like core of α-synuclein protofibril and its disruption by dopamine and norepinephrine
The formation of amyloid fibrils by α-synuclein (αS) protein inside the Lewy bodies and Lewy
neurites is the prominent pathological hallmark of Parkinson's disease (PD). The fibrillation …
neurites is the prominent pathological hallmark of Parkinson's disease (PD). The fibrillation …