mRNA vaccines for cancer immunotherapy

YL Vishweshwaraiah, NV Dokholyan - Frontiers in immunology, 2022 - frontiersin.org
Immunotherapy has emerged as a breakthrough strategy in cancer treatment. mRNA
vaccines are an attractive and powerful immunotherapeutic platform against cancer because …

Epitopes and mimotopes identification using phage display for vaccine development against infectious pathogens

M Palma - Vaccines, 2023 - mdpi.com
Traditional vaccines use inactivated or weakened forms of pathogens which could have side
effects and inadequate immune responses. To overcome these challenges, phage display …

A nanoparticle vaccine displaying conserved epitopes of the preexisting neutralizing antibody confers broad protection against SARS-CoV-2 variants

X Wu, W Li, H Rong, J Pan, X Zhang, Q Hu, ZL Shi… - ACS …, 2024 - ACS Publications
The rapid development of the SARS-CoV-2 vaccine has been used to prevent the spread of
coronavirus 2019 (COVID-19). However, the ongoing and future pandemics caused by …

Biomotors, viral assembly, and RNA nanobiotechnology: Current achievements and future directions

L Rolband, D Beasock, Y Wang, YG Shu… - Computational and …, 2022 - Elsevier
Abstract The International Society of RNA Nanotechnology and Nanomedicine (ISRNN)
serves to further the development of a wide variety of functional nucleic acids and other …

Toehold-mediated shape transition of nucleic acid nanoparticles

J Hartung, N McCann, E Doe, H Hayth… - … applied materials & …, 2023 - ACS Publications
We introduce a toehold-mediated strand displacement strategy for regulated shape-
switching of nucleic acid nanoparticles (NANPs) enabling their sequential transformation …

From De Novo Design to Redesign: Harnessing Computational Protein Design for Understanding SARS-CoV-2 Molecular Mechanisms and Developing Therapeutics

AK Padhi, P Kalita, S Maurya, KM Poluri… - The Journal of …, 2023 - ACS Publications
The continuous emergence of novel SARS-CoV-2 variants and subvariants serves as
compelling evidence that COVID-19 is an ongoing concern. The swift, well-coordinated …

An engineered N-acyltransferase-LOV2 domain fusion protein enables light-inducible allosteric control of enzymatic activity

JA Reynolds, YL Vishweshwaraiah… - Journal of Biological …, 2023 - ASBMB
Transferases are ubiquitous across all known life. While much work has been done to
understand and describe these essential enzymes, there have been minimal efforts to exert …

A Piecewise Design Approach to Engineering a Miniature ACE2 Mimic to Bind SARS-CoV-2

YL Vishweshwaraiah, B Hnath, J Wang… - ACS Applied Bio …, 2024 - ACS Publications
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues its global
spread, the exploration of novel therapeutic and diagnostic strategies is still needed. The …

Enhanced Antibody Response to the Conformational Non-RBD Region via DNA Prime-Protein Boost Elicits Broad Cross-Neutralization Against SARS-CoV-2 …

YF Ma, K Chen, B Xie, J Zhu, X He, C Chen… - Emerging Microbes & …, 2024 - Taylor & Francis
Preventing immune escape of SARS-CoV-2 variants is crucial in vaccine development to
ensure broad protection against the virus. Conformational epitopes beyond the RBD region …

[PDF][PDF] Epitopes and Mimotopes Identification Using Phage Display for Vaccine Development against Infectious Pathogens. Vaccines 2023, 11, 1176

M Palma - 2023 - researchgate.net
Traditional vaccines use inactivated or weakened forms of pathogens which could have side
effects and inadequate immune responses. To overcome these challenges, phage display …