The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

With the identification of activating mutations in BRAF across a wide variety of malignancies,
substantial effort was placed in designing safe and effective therapeutic strategies to target …

Langerhans cell histiocytosis (LCH) can affect children and adults with a wide variety of
clinical manifestations, including unifocal, single-system multifocal, single-system pulmonary …

ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 in
3 infants with multisystemic disease involving the liver and hematopoietic system. This entity …

This manuscript represents a review of lymphoblastic leukemia/lymphoma (acute
lymphoblastic leukemia/lymphoblastic lymphoma), acute leukemias of ambiguous lineage …

Histiocytoses constitute a heterogeneous group of rare disorders, characterised by
infiltration of almost any organ by myeloid cells with diverse macrophage or dendritic cell …

Histiocytic neoplasms are rare hematologic disorders accounting for less than 1% of cancers
of the soft tissue and lymph nodes. Clinical presentation and prognosis of these disorders …

Erdheim-Chester disease (ECD) is a rare, multisystemic, inflammatory, non–Langerhans cell
histiocytic neoplasm. The discovery of recurrent and somatic mutations in the mitogen …

Histiocytoses are heterogeneous hematopoietic diseases characterized by the accumulation
of CD68 (+) cells with various admixed inflammatory infiltrates. The identification of the …

Children with Langerhnans cell histiocytosis (LCH) develop granulomatous lesions with
characteristic clonal CD207+ dendritic cells that can arise as single lesions or life …