Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying
pathobiology of COVID-19 will support the design of rational treatments targeting the life …

Natural products and synthetic small molecules can be used to perturb, dissect and
manipulate biological processes, thereby providing the basis for drug development. Over the …

Rapidly growing interest in the nanoparticle-mediated delivery of DNA and RNA to plants
requires a better understanding of how nanoparticles and their cargoes translocate in plant …

Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and has resulted in hundreds of thousands of …

Tumor biomarkers are a kind of important biomolecules for aiding cancer diagnosis and
assessing tumor efficacy, among which alpha-fetoprotein (AFP) is a crucial tumor biomarker …

Emergence of SARS‐CoV‐2 variants warrants sustainable efforts to upgrade both the
diagnostic and therapeutic protocols. Understanding the details of cellular and molecular …

The search for immunostimulatory drugs applicable to cancer immunotherapy may profit
from target‐agnostic methods in which agents are screened for their functional impact on …

Viral diseases are emerging as global threats. Severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), that causes coronavirus disease (COVID-19), has severe …

Endocytosis is one of the major ways cells communicate with their environment. This
process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic …

Activation of the JAK–STAT pathway by type I interferons (IFNs) requires clathrin-dependent
endocytosis of the IFN-α and-β receptor (IFNAR), indicating a role for endosomal sorting in …