Structural simplification of natural products

S Wang, G Dong, C Sheng - Chemical Reviews, 2019 - ACS Publications
Natural products (NPs) are important sources of clinical drugs due to their structural diversity
and biological prevalidation. However, the structural complexity of NPs leads to synthetic …

Fragment coupling with tertiary radicals generated by visible-light photocatalysis

CR Jamison, LE Overman - Accounts of Chemical Research, 2016 - ACS Publications
Conspectus Convergent synthesis strategies in which a target molecule is prepared by a
branched approach wherein two or more complex fragments are combined at a late stage …

Total synthesis of complex terpenoids employing radical cascade processes

K Hung, X Hu, TJ Maimone - Natural product reports, 2018 - pubs.rsc.org
Covering: 2011–2017 Radical cyclizations have a rich history in organic chemistry and have
been particularly generous to the field of natural product synthesis. Owing to their ability to …

A concise synthesis of (−)‐aplyviolene facilitated by a strategic tertiary radical conjugate addition

MJ Schnermann, LE Overman - Angewandte Chemie, 2012 - Wiley Online Library
Aplyviolene (1) and macfarlandinE (2, Scheme1A) are representative of the more complex
members of the rearranged spongian diterpene class of natural products.[1, 2] These …

Transition Metal‐Mediated C− C Single Bond Cleavage: Making the Cut in Total Synthesis

B Wang, MA Perea, R Sarpong - … Chemie International Edition, 2020 - Wiley Online Library
Transition‐metal‐mediated cleavage of C− C single bonds can enable entirely new
retrosynthetic disconnections in the total synthesis of natural products. Given that C− C bond …

Bridging the gap between natural product synthesis and drug discovery

NJ Truax, D Romo - Natural product reports, 2020 - pubs.rsc.org
Covering: 1986 to 2020 Natural products are an enduring source of chemical information
useful for probing biologically relevant chemical space. Toward gathering further structure …

Capturing biological activity in natural product fragments by chemical synthesis

EA Crane, K Gademann - Angewandte Chemie International …, 2016 - Wiley Online Library
Natural products have had an immense influence on science and have directly led to the
introduction of many drugs. Organic chemistry, and its unique ability to tailor natural products …

Simplified immunosuppressive and neuroprotective agents based on gracilin A

ME Abbasov, R Alvariño, CM Chaheine, E Alonso… - Nature …, 2019 - nature.com
The architecture and bioactivity of natural products frequently serve as embarkation points
for the exploration of biologically relevant chemical space. Total synthesis followed by …

Bioactive compounds from marine heterobranchs

C Avila, C Angulo-Preckler - Marine Drugs, 2020 - mdpi.com
The natural products of heterobranch molluscs display a huge variability both in structure
and in their bioactivity. Despite the considerable lack of information, it can be observed from …

The potential of Indonesian heterobranchs found around Bunaken Island for the production of bioactive compounds

KM Fisch, C Hertzer, N Böhringer, ZG Wuisan… - Marine drugs, 2017 - mdpi.com
The species diversity of marine heterobranch sea slugs found on field trips around Bunaken
Island (North Sulawesi, Indonesia) and adjacent islands of the Bunaken National Marine …