Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …

Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary
disease with a median survival of 2–4 years after diagnosis. A significant number of IPF …

Multiple genetic changes occur during the evolution of normal cells into cancer cells. This
evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair …

Abstract p53 antibodies (p53-Abs) were discovered 20 years ago during the course of tumor-
associated antigens screening. The discovery of p53 mutation and accumulation of p53 in …

The lung is a highly specialized organ that facilitates uptake of oxygen and release of
carbon dioxide. Due to its unique structure providing enormous surface area to outside …

Aberrant methylation of CpG islands acquired in tumor cells in promoter regions is one
method for loss of gene function. We determined the frequency of aberrant promoter …

Recent studies from our laboratory suggest that gene-specific methylation changes in
sputum could be good intermediate markers for the early detection of lung cancer and …

Lung cancer is the most common worldwide cause of major cancer incidence and mortality.
97 It is estimated that lung cancer will account for more than 169,500 new cases in the …

Solid lipid nanoparticles (SLN) are considered at the forefront of nanotechnology's rapidly
developing field, with several potential applications in drug delivery and research. SLN …

Gene-based therapies for cancer in clinical trials include strategies that involve
augmentation of immunotherapeutic and chemotherapeutic approaches. These strategies …