Sequential expression of claudins, a family of tight junction proteins, along the nephron
mirrors the sequential expression of ion channels and transporters. Only by the interplay of …

Claudins are integral proteins expressed at the tight junctions of epithelial and endothelial
cells. In the mammalian kidney, every tubular segment express a specific set of claudins that …

Renal Ca2+ reabsorption is essential for maintaining systemic Ca2+ homeostasis and is
tightly regulated through the parathyroid hormone (PTH)/PTHrP receptor (PTH1R) signaling …

Food intake plays a pivotal role in human growth, constituting 45% of the global economy
and wellbeing in general. The consumption of a balanced diet is essential for overall good …

Context Urolithiasis has a high prevalence and recurrence rate. Prevention is key to patient
management, but risk stratification is challenging. In particular, genetic predisposition for …

Kidney stone disease comprising nephrolithiasis and nephrocalcinosis is a clinical
syndrome of increasing prevalence with remarkable heterogeneity. Stone composition, age …

Calcium-sensing receptor (CaSR) is a plasma-membrane G protein-coupled receptor
activated by extracellular calcium and expressed in kidney tubular cells. It inhibits calcium …

Objective: This study explores associations between recurrent kidney stones and genetic
polymorphisms. Methods: Meta-analysis of polymorphisms in renal stone cases versus …

The thick ascending limb plays a central role in human kidney physiology, participating in
sodium reabsorption, urine concentrating mechanisms, calcium and magnesium …

Objectives To explore the mechanism of calcium-sensing receptors (CaSRs) during the
development of nephrolithiasis. Materials and methods Wistar rats were treated with …