Sub-Saharan Africa carries the highest burden of HIV-1 and AIDS. About 39% of all new
infections in the world in 2020 were in this region. Oral PrEP was found to be very effective …

Long-acting injectable medications, such as atovaquone, offer the prospect of a “chemical
vaccine” for malaria, combining drug efficacy with vaccine durability. However, selection and …

Background HIV-1 infection continues to affect global health. Although antiretrovirals can
reduce the viral load or prevent HIV-1 infection, current drugs require daily oral use with a …

Antiretroviral therapy (ART) is a major method of HIV and AIDS treatment; however, it has
several limitations, such as poor drug availability, cytotoxicity or renal clearance of the drug …

Microarray patches (MAPs) are currently under investigation as a self-administered, pain-
free alternative used to achieve long-acting (LA) drug delivery. Cabotegravir is a potent …

Background Acquired syphilis continues to affect millions of people around the world. It is
crucial to study it in the context of HIV Pre-Exposure Prophylaxis (PrEP) to achieve the goals …

The long-acting feature of cabotegravir, an integrase-inhibitor highly effective in preventing
acquisition of HIV in adolescents and adults, is both its greatest strength and a challenge to …

Objectives: We wished to assess time to protection from HIV-1 infection following oral
tenofovir disoproxil and emtricitabine (TDF/FTC) as preexposure prophylaxis (PrEP), using …

The human immunodeficiency virus (HIV) was unknown until the early 1980's when
increasing numbers of cases of unusual opportunistic infections and Kaposi sarcoma in …

The emergence of drug resistance during antimicrobial therapy is a major global health
problem, especially for chronic infections like human immunodeficiency virus, hepatitis B …