A multiscale analysis of early flower development in Arabidopsis provides an integrated view of molecular regulation and growth control
We have analyzed the link between the gene regulation and growth during the early stages
of flower development in Arabidopsis. Starting from time-lapse images, we generated a 4D …
of flower development in Arabidopsis. Starting from time-lapse images, we generated a 4D …
Dissecting Mechanisms of Epigenetic Memory Through Computational Modeling
A Briffa, G Menon… - Annual Review of …, 2024 - annualreviews.org
Understanding the mechanistic basis of epigenetic memory has proven to be a difficult task
due to the underlying complexity of the systems involved in its establishment and …
due to the underlying complexity of the systems involved in its establishment and …
A minimal regulatory network of extrinsic and intrinsic factors recovers observed patterns of CD4+ T cell differentiation and plasticity
ME Martinez-Sanchez, L Mendoza… - PLoS computational …, 2015 - journals.plos.org
CD4+ T cells orchestrate the adaptive immune response in vertebrates. While both
experimental and modeling work has been conducted to understand the molecular genetic …
experimental and modeling work has been conducted to understand the molecular genetic …
A network model to describe the terminal differentiation of B cells
Terminal differentiation of B cells is an essential process for the humoral immune response
in vertebrates and is achieved by the concerted action of several transcription factors in …
in vertebrates and is achieved by the concerted action of several transcription factors in …
A dynamic genetic-hormonal regulatory network model explains multiple cellular behaviors of the root apical meristem of Arabidopsis thaliana
ML García-Gómez, E Azpeitia… - PLoS computational …, 2017 - journals.plos.org
The study of the concerted action of hormones and transcription factors is fundamental to
understand cell differentiation and pattern formation during organ development. The root …
understand cell differentiation and pattern formation during organ development. The root …
Taming asynchrony for attractor detection in large Boolean networks
Boolean networks is a well-established formalism for modelling biological systems. A vital
challenge for analyzing a Boolean network is to identify all the attractors. This becomes …
challenge for analyzing a Boolean network is to identify all the attractors. This becomes …
The flowering transition pathways converge into a complex gene regulatory network that underlies the phase changes of the shoot apical meristem in Arabidopsis …
EC Chávez-Hernández, S Quiroz… - Frontiers in Plant …, 2022 - frontiersin.org
Post-embryonic plant development is characterized by a period of vegetative growth during
which a combination of intrinsic and extrinsic signals triggers the transition to the …
which a combination of intrinsic and extrinsic signals triggers the transition to the …
A quantitative and dynamic model of the Arabidopsis flowering time gene regulatory network
Various environmental signals integrate into a network of floral regulatory genes leading to
the final decision on when to flower. Although a wealth of qualitative knowledge is available …
the final decision on when to flower. Although a wealth of qualitative knowledge is available …
A Dynamic Gene Regulatory Network Model That Recovers the Cyclic Behavior of Arabidopsis thaliana Cell Cycle
E Ortiz-Gutiérrez, K García-Cruz… - PLoS computational …, 2015 - journals.plos.org
Cell cycle control is fundamental in eukaryotic development. Several modeling efforts have
been used to integrate the complex network of interacting molecular components involved in …
been used to integrate the complex network of interacting molecular components involved in …
A Boolean network model of human gonadal sex determination
Background Gonadal sex determination (GSD) in humans is a complex biological process
that takes place in early stages of embryonic development when the bipotential gonadal …
that takes place in early stages of embryonic development when the bipotential gonadal …