Regulation of alphaherpesvirus infections by the ICP0 family of proteins
C Boutell, RD Everett - Journal of General Virology, 2013 - microbiologyresearch.org
Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the
regulation of lytic and latent viral infection. Like the related proteins expressed by other …
regulation of lytic and latent viral infection. Like the related proteins expressed by other …
[HTML][HTML] The HSV-1 ubiquitin ligase ICP0: Modifying the cellular proteome to promote infection
Abstract Herpes simplex virus 1 (HSV-1) hijacks ubiquitination machinery to modify the
cellular proteome to create an environment permissive for virus replication. HSV-1 encodes …
cellular proteome to create an environment permissive for virus replication. HSV-1 encodes …
[HTML][HTML] Virus-mediated suppression of the antigen presentation molecule MR1
The antigen-presenting molecule MR1 presents microbial metabolites related to vitamin B2
biosynthesis to mucosal-associated invariant T cells (MAIT cells). Although bacteria and …
biosynthesis to mucosal-associated invariant T cells (MAIT cells). Although bacteria and …
Herpes simplex virus 1 ubiquitin ligase ICP0 interacts with PML isoform I and induces its SUMO-independent degradation
D Cuchet-Lourenço, E Vanni, M Glass, A Orr… - Journal of …, 2012 - Am Soc Microbiol
ABSTRACT Herpes simplex virus 1 (HSV-1) immediate-early protein ICP0 localizes to
cellular structures known as promyelocytic leukemia protein (PML) nuclear bodies or ND10 …
cellular structures known as promyelocytic leukemia protein (PML) nuclear bodies or ND10 …
“Non-essential” proteins of HSV-1 with essential roles in vivo: a comprehensive review
C Dogrammatzis, H Waisner, M Kalamvoki - Viruses, 2020 - mdpi.com
Viruses encode for structural proteins that participate in virion formation and include capsid
and envelope proteins. In addition, viruses encode for an array of non-structural accessory …
and envelope proteins. In addition, viruses encode for an array of non-structural accessory …
Regulators and effectors of Siah ubiquitin ligases
The Siah ubiquitin ligases are members of the RING finger E3 ligases. The Siah E3s are
conserved from fly to mammals. Primarily implicated in cellular stress responses, Siah …
conserved from fly to mammals. Primarily implicated in cellular stress responses, Siah …
Bortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic antitumor effects
JY Yoo, BS Hurwitz, C Bolyard, JG Yu, J Zhang… - Clinical cancer …, 2014 - AACR
Background: Bortezomib is an FDA-approved proteasome inhibitor, and oncolytic herpes
simplex virus-1 (oHSV) is a promising therapeutic approach for cancer. We tested the impact …
simplex virus-1 (oHSV) is a promising therapeutic approach for cancer. We tested the impact …
Siah1 in cancer and nervous system diseases
H Zhang, J Wang, Y Ge, M Ye, X Jin - Oncology reports, 2022 - spandidos-publications.com
The dysregulation of the ubiquitin‑proteasome system will result in the abnormal
accumulation and dysfunction of proteins, thus leading to severe diseases. Seven in …
accumulation and dysfunction of proteins, thus leading to severe diseases. Seven in …
Identification of TRIM27 as a novel degradation target of herpes simplex virus 1 ICP0
The herpes simplex virus 1 (HSV-1) immediate early protein ICP0 performs many functions
during infection, including transactivation of viral gene expression, suppression of innate …
during infection, including transactivation of viral gene expression, suppression of innate …
Roles of p53 in herpes simplex virus 1 replication
Y Maruzuru, H Fujii, M Oyama, H Kozuka-Hata… - Journal of …, 2013 - Am Soc Microbiol
ABSTRACT p53 is a critical factor in the cellular response to a broad range of stress factors
through its ability to regulate various cellular pathways. In this study, tandem affinity …
through its ability to regulate various cellular pathways. In this study, tandem affinity …