Eph receptors and ephrins: therapeutic opportunities

A Barquilla, EB Pasquale - Annual review of pharmacology and …, 2015 - annualreviews.org
The e rythropoietin-p roducing h epatocellular carcinoma (Eph) receptor tyrosine kinase
family plays important roles in developmental processes, adult tissue homeostasis, and …

Criteria to define mild, moderate, and severe traumatic brain injury in the mouse controlled cortical impact model

L Siebold, A Obenaus, R Goyal - Experimental neurology, 2018 - Elsevier
Traumatic brain injury (TBI) is a major health concern in the United States resulting in a
substantial number of hospitalizations and in a broad spectrum of symptoms and disabilities …

Overexpression of Sox11 promotes corticospinal tract regeneration after spinal injury while interfering with functional recovery

Z Wang, A Reynolds, A Kirry, C Nienhaus… - Journal of …, 2015 - Soc Neuroscience
Embryonic neurons, peripheral neurons, and CNS neurons in zebrafish respond to axon
injury by initiating pro-regenerative transcriptional programs that enable axons to extend …

Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury

EJ Perez, SA Tapanes, ZB Loris… - The Journal of …, 2017 - Am Soc Clin Investig
After traumatic brain injury (TBI), glial cells have both beneficial and deleterious roles in
injury progression and recovery. However, few studies have examined the influence of …

Loss of NLRX1 exacerbates neural tissue damage and NF-κB signaling following brain injury

MH Theus, T Brickler, AL Meza… - The Journal of …, 2017 - journals.aai.org
Traumatic and nontraumatic brain injury results from severe disruptions in the cellular
microenvironment leading to massive loss of neuronal populations and increased …

Nonessential role for the NLRP1 inflammasome complex in a murine model of traumatic brain injury

T Brickler, K Gresham, A Meza… - Mediators of …, 2016 - Wiley Online Library
Traumatic brain injury (TBI) elicits the immediate production of proinflammatory cytokines
which participate in regulating the immune response. While the mechanisms of adaptive …

Angiopoietin/Tie2 axis regulates the age-at-injury cerebrovascular response to traumatic brain injury

TR Brickler, A Hazy, FG Correa, R Dai… - Journal of …, 2018 - Soc Neuroscience
Although age-at-injury influences chronic recovery from traumatic brain injury (TBI), the
differential effects of age on early outcome remain understudied. Using a male murine …

DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury

MM Díaz, Y Tsenkina, D Arizanovska… - Cell Death & …, 2023 - nature.com
Hallmark pathological features of brain trauma are axonal degeneration and demyelination
because myelin-producing oligodendrocytes (OLs) are particularly vulnerable to injury …

The role of Ephs and Ephrins in memory formation

M Dines, R Lamprecht - International Journal of …, 2016 - academic.oup.com
The ability to efficiently store memories in the brain is a fundamental process and its
impairment is associated with multiple human mental disorders. Evidence indicates that long …

EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental …

ST Liu, SM Zhong, XY Li, F Gao, F Li, ML Zhang… - Acta neuropathologica …, 2018 - Springer
It was previously shown that EphB/ephrinB reverse signaling in retinal ganglion cells
(RGCs) is activated and involved in RGC apoptosis in a rat chronic ocular hypertension …