Disease modeling and target identification are the most crucial initial steps in drug
discovery, and influence the probability of success at every step of drug development …

Cancer is one of the leading causes of human death. MicroRNAs have been found to be
closely associated with cancer. The miR-183 cluster, comprising miR-183, miR-96, and miR …

Parkinson's Disease (PD) is caused by many factors and endoplasmic reticulum (ER) stress
is considered as one of the responsible factors for it. ER stress induces the activation of the …

Although the prognosis for papillary thyroid carcinoma (PTC) is generally good, a certain
proportion of patients show recurrent or advanced disease, indicating the need for further …

Papillary thyroid carcinoma (PTC) is one of the most common endocrine carcinomas
worldwide and the aetiology of this cancer is still not well understood. Therefore, it remains …

Chronic inflammation is an important contributor to tumorigenesis in many tissues. However,
the underlying mechanisms of inflammatory signaling in the tumor microenvironment are not …

Cancer hallmark genes and proteins orchestrate and drive carcinogenesis to a large extent,
therefore, it is important to study these features in different cancer types to understand the …

Thyroid cancer (TC) and thyroid autoimmune disorders (AITD) are among the most common
diseases in the general population, with higher incidence in women. Chronic inflammation …

Gastric cancer (GC) is one of the five most common cancers in the world and unfortunately
has a high mortality rate. To date, the pathogenesis and disease genes of GC are unclear …

The poorly differentiated thyroid carcinoma (THCA) subtype is associated with an
aggressive disease course, a less favorable overall prognosis, and an increased risk of …