Substantial progress in understanding T cell signalling, particularly with respect to T cell co-
receptors such as the co-stimulatory receptor CD28, has been made in recent years. This …

Post-transcriptional regulation by RNA binding proteins can determine gene expression
levels and drive changes in cancer cell proteomes. Identifying mechanisms of protein-RNA …

CD8+ T cells kill target cells by releasing cytotoxic molecules and proinflammatory
cytokines, such as TNF and IFN‐γ. The magnitude and duration of cytokine production are …

Aims RNA-binding proteins (RBPs) play pivotal roles in carcinogenesis and immunotherapy.
Leucine-rich pentapeptide repeat-containing protein (LRPPRC) is crucial for RNA …

Hydroxyglutarate (2HG) is a byproduct of the tricarboxylic acid (TCA) cycle and is readily
detected in the tissues of healthy individuals. 2HG is found in two enantiomeric forms: S …

RNA-binding proteins (RBPs) are essential effectors in defining and regulating gene
expression, and as such their function underlies all cellular processes. Within the immune …

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Maintaining immune homeostasis is instrumental for host health. Immune cells, such as T
cells, are instrumental for the eradication of pathogenic bacteria, fungi and viruses …

As part of the adaptive immune system, T cells are critical to maintain immune homeostasis.
T cells provide protective immunity by killing infected cells and combatting cancerous cells …

To maintain lineage-specific functions, cells must acquire and allocate nutrients across
diverse cellular processes, even in metabolically-dysregulated environments. The …