One literature treats the hippocampus as a purely cognitive structure involved in memory;
another treats it as a regulator of emotion whose dysfunction leads to psychopathology. We …

The mechanistic operation of brain regions is often interpreted by partitioning constituent
neurons into 'cell types'. Historically, such cell types were broadly defined by their …

The dentate gyrus (DG), in addition to its role in learning and memory, is increasingly
implicated in the pathophysiology of anxiety disorders. Here, we show that, dependent on …

Although an influence of adult neurogenesis in mediating some of the effects of
antidepressants has received considerable attention in recent years, much less is known …

The empathic ability to vicariously experience the other's fearful situation, a process called
observational fear (OF), is critical to survive in nature and function in society. OF can be …

Posttraumatic stress disorder (PTSD) is characterized by a hypermnesia of the trauma and
by a memory impairment that decreases the ability to restrict fear to the appropriate context …

Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of
Alzheimer's disease (AD), but most abnormally expressed miRNAs found in AD are not …

In recent years, both major depression and antidepressant therapy have been linked to adult
hippocampal neurogenesis. The hippocampus is not a homogeneous brain area, and a …

Memories can be recalled at different levels of resolution, from a detailed rendition of
specific events within a single experience to a broad generalization across multiple related …

To identify the role of the histone acetyltransferase (HAT) CREB-binding protein (CBP) in
neurons of the CA1 region of the hippocampus during memory formation, we examine the …