Over the last twenty years, fluorination on nucleoside has established itself as the most
promising tool to use to get biologically active compounds that could sustain the clinical trial …

With the ever-increasing scope of organocuprates, a well-established Gilman reagent has
been considered as an unprecedented synthetic tool in modern organic chemistry. The …

The 6′-fluorinated aristeromycins were designed as dual-target antiviral compounds aimed
at inhibiting both the viral RNA-dependent RNA polymerase (RdRp) and the host cell S …

Analogues of the canonical nucleosides have a longstanding presence and proven
capability within medicinal chemistry and drug discovery research. The synthesis reported …

We have reported on aristeromycin (1) and 6′-fluorinated-aristeromycin analogues (2),
which are active against RNA viruses such as Middle East respiratory syndrome coronavirus …

We describe an efficient and stereoselective synthesis of 1′-substituted-β-carbocylic
nucleosides 5 via gem-dichlorooxirane intermediate 7, which directly condensed with weak …

The conformation of the central five-membered ring of a nucleoside plays an important role
in enzyme recognition. Bicyclo [3.1. 0] hexane, also known as the methanocarba (MC) …

Parasite Plasmodium falciparum is continuously giving a challenge to human beings by
changing itself against most of the antimalarial drugs and its consequences can be seen in …

MLN4924 is known for its potential in cancer treatment and antiviral activity as a NEDD8‐
activating enzyme (NAE) inhibitor. We designed and synthesized fluorinated MLN4924 …

The synthesis of novel nucleoside analogues bearing a C3′ all-carbon quaternary center
and a C2′-hydroxy substituent is described. The all-carbon stereogenic center was …