The hippocampal formation (HPC) and medial prefrontal cortex (mPFC) have well-
established roles in memory encoding and retrieval. However, the mechanisms underlying …

The nucleus reuniens of the thalamus (RE) is a key component of an extensive network of
hippocampal and cortical structures and is a fundamental substrate for cognition. A common …

Episodic memory-based decision-making requires top-down medial prefrontal cortex and
hippocampal interactions. This integrated prefrontal-hippocampal memory state is thought to …

The thalamus was subdivided into three major groups: sensorimotor nuclei (or
principal/relay nuclei), limbic nuclei and nuclei bridging these two domains. Limbic nuclei of …

The intralaminar and medial thalamic nuclei are part of the higher-order thalamus, which
receives little sensory input, and instead forms extensive cortico-thalamo-cortical pathways …

The medial prefrontal cortex (mPFC) participates in several higher order functions including
selective attention, visceromotor control, decision making and goal-directed behaviors. We …

The reuniens and rhomboid nuclei, located in the ventral midline of the thalamus, have long
been regarded as having non-specific effects on the cortex, while other evidence suggests …

The paraventricular (PV) and paratenial (PT) nuclei are prominent cell groups of the midline
thalamus. To our knowledge, only a single early report has examined PV projections and no …

The nucleus reuniens (RE) is the largest of the midline nuclei of the thalamus and exerts
strong excitatory actions on the hippocampus and medial prefrontal cortex. Although RE …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
loss of cognitive functions, reflecting pathological damage to the medial prefrontal cortex …