Flavin-based electron bifurcation is a newly discovered mechanism, by which a hydride
electron pair from NAD (P) H, coenzyme F420H2, H2, or formate is split by flavoproteins into …

Strains of Clostridioides difficile cause detrimental diarrheas with thousands of deaths
worldwide. The infection process by the Gram-positive, strictly anaerobic gut bacterium is …

Clostridium difficile is the largest single cause of hospital-acquired infection in the United
States. A major risk factor for Clostridium difficile infection (CDI) is prior exposure to …

Butyric acid is an important platform chemical, which is widely used in the fields of food,
pharmaceutical, energy, etc. Microbial fermentation as an alternative approach for butyric …

For prototrophic bacteria, central metabolism (ie, glycolysis, the pentose phosphate
pathway, and the Krebs cycle) supplies the 13 biosynthetic intermediates necessary to …

Biomanufacturing from renewable feedstocks can offset fossil fuel-based chemical
production. One potential biomanufacturing strategy is production of medium-chain fatty …

The electron transferring flavoprotein/butyryl-CoA dehydrogenase (EtfAB/Bcd) catalyzes the
reduction of one crotonyl-CoA and two ferredoxins by two NADH within a flavin-based …

Roseburia species are important denizens of the human gut microbiome that ferment
complex polysaccharides to butyrate as a terminal fermentation product, which influences …

Stickland amino acid fermentations occur primarily among species of Clostridia. An ancient
form of metabolism, Stickland fermentations use amino acids as electron acceptors in the …

The obligate anaerobe, spore forming bacterium Clostridioides difficile (formerly Clostridium
difficile) causes nosocomial and community acquired diarrhea often associated with …