The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …

Stalling during translation triggers ribosome quality control (RQC) to maintain proteostasis.
Recently, stalling has also been linked to the activation of integrated stress response (ISR) …

Multiple Sclerosis (MS) is an immune-mediated neurological disorder, characterized by
central nervous system (CNS) inflammation, oligodendrocyte loss, demyelination, and …

Neuroinflammation and endoplasmic reticulum (ER) stress are associated with many
neurological diseases. Here, we have examined the interaction between ER stress and …

A lack of sufficient oligodendrocyte myelination contributes to remyelination failure in
demyelinating disorders. miRNAs have been implicated in oligodendrogenesis; however …

Olfactory sensory neurons (OSNs) convert the stochastic choice of one of> 1,000 olfactory
receptor (OR) genes into precise and stereotyped axon targeting of OR-specific glomeruli in …

Neuronal death and inflammatory response are two common pathological hallmarks of
acute central nervous system injury and chronic degenerative disorders, both of which are …

The endoplasmic reticulum (ER) is a critical organelle for normal cell function and
homeostasis. Disturbance in the protein folding process in the ER, termed ER stress, leads …