By 2050, the aging population is predicted to expand by over 100%. Considering this rapid
growth, and the additional strain it will place on healthcare resources because of age …

The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

Astrocytes become activated (reactive) in response to many CNS pathologies, such as
stroke, trauma, growth of a tumor, or neurodegenerative disease. The process of astrocyte …

The circuitry of the human brain is formed by neuronal networks embedded into astroglial
syncytia. The astrocytes perform numerous functions, providing for the overall brain …

Astrocytes extend endfeet that enwrap the vasculature, and disruptions to this association
which may occur in disease coincide with breaches in blood-brain barrier (BBB) integrity …

Astroglia represent a class of heterogeneous, in form and function, cells known as
astrocytes, which provide for homoeostasis and defence of the central nervous system …

Progressive neuronal loss and cognitive decline in Alzheimer's disease (AD) might be
aggravated by β-amyloid-enhanced excitotoxicity. Memantine is an uncompetitive NMDA …

Understanding the role of astrocytes in the central nervous system has changed dramatically
over the last decade. The accumulating findings indicate that glial cells are involved not only …

Extensive tau-immunoreactive neurons and glial cells associated with chronic traumatic
encephalopathy (CTE) have been documented in the brains of some professional athletes …

Old age is associated with enhanced susceptibility to and poor recovery from brain injury. An
exacerbated microglial and astrocyte response to brain injury might be involved in poor …