Abstract In 1964, Vincent Allfrey and colleagues reported the identification of histone
acetylation and with deep insight proposed a regulatory role for this protein modification in …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Low-complexity protein domains promote the formation of various biomolecular
condensates. However, in many cases, the precise sequence features governing …

Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly
influenced by the post-translational modification of histones, the building blocks of …

Cytosine residues in the sequence 5′ CpG (cytosine–guanine) are often postsynthetically
methylated in animal genomes. CpG methylation is involved in long-term silencing of certain …

Histone acetylation in chromatin structure and transcription | Nature Skip to main content
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Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and
physiological function of virtually all tissues. TH binds to receptors that are ligand …

During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …

The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a
sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be …

Histone deacetylases (HDACs) play important roles in transcriptional regulation and
pathogenesis of cancer. Thus, HDAC inhibitors are candidate drugs for differentiation …