Due to their involvement in numerous biochemical pathways, neuropeptides have been the
focus of many recent research studies. Unfortunately, classic analytical methods, such as …

This Tutorial is to provide a summary of parameters useful for successful outcomes of
laserspray ionization (LSI) and related methods that employ a laser to ablate a matrix …

Mechanistic arguments relative to matrix-assisted laser desorption/ionization (MALDI) mass
spectrometry (MS) address observations that predominately singly charged ions are …

The systematic study of the temperature and pressure dependence of matrix-assisted
ionization (MAI) led us to the discovery of the seemingly impossible, initially explained by …

An astonishingly simple new method to produce gas-phase ions of small molecules as well
as proteins from the solid state under cold vacuum conditions is described. This matrix …

Matrix assisted inlet ionization (MAII) is a method in which a matrix: analyte mixture
produces mass spectra nearly identical to electrospray ionization without the application of a …

Neuropeptides are important mediators in the functionality of the brain and other
neurological organs. Because neuropeptides exist in a wide range of concentrations …

The initial discovery that a heated inlet tube of a mass spectrometer is an ionization source
producing ions from volatile, nonvolatile, small, and large molecules with charge states …

Inlet ionization is a new approach for ionizing both small and large molecules in solids or
liquid solvents with high sensitivity. The utility of solvent based inlet ionization mass …

Desorption electrospray ionization mass spectrometry (DESI‐MS) requires little to no sample
preparation and has been successfully applied to the study of biologically significant …